1GXC

FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide

1GXC の概要

• エントリーDOI: 10.2210/pdb1gxc/pdb
• 分子名称: SERINE/THREONINE-PROTEIN KINASE CHK2, SYNTHETIC PHOSPHOPEPTIDE (3 entities in total)
• 機能のキーワード: phosphoprotein-binding domain, checkpoint kinase, transferase, serine/threonine-protein kinase
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 75587.18

構造登録者

Li, J.,Williams, B.L.,Haire, L.F.,Goldberg, M.,Wilker, E.,Durocher, D.,Yaffe, M.B.,Jackson, S.P.,Smerdon, S.J. (登録日: 2002-04-02, 公開日: 2002-06-13, 最終更新日: 2016-12-21)

• 主引用文献: Li, J.,Williams, B.L.,Haire, L.F.,Goldberg, M.,Wilker, E.,Durocher, D.,Yaffe, M.B.,Jackson, S.P.,Smerdon, S.J.; Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2; Mol.Cell, 9:1045-, 2002; PubMed: 12049740; DOI: 10.1016/S1097-2765(02)00527-0

実験手法

X-RAY DIFFRACTION (2.7 Å)