1GUX

RB POCKET BOUND TO E7 LXCXE MOTIF

1GUX の概要

• エントリーDOI: 10.2210/pdb1gux/pdb
• 分子名称: RETINOBLASTOMA PROTEIN, ONCOPROTEIN, ... (4 entities in total)
• 機能のキーワード: complex (transcription regulation-peptide), tumor suppressor protein, retinoblastoma, complex (transcription reg-peptide) complex, complex (transcription reg/peptide)
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44526.64

構造登録者

Lee, J.O.,Russo, A.A.,Pavletich, N.P. (登録日: 1997-11-15, 公開日: 1998-12-02, 最終更新日: 2024-02-07)

主引用文献

Lee, J.O.,Russo, A.A.,Pavletich, N.P.
Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7.
Nature, 391:859-865, 1998

PubMed Abstract: The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB.

PubMed: 9495340
DOI: 10.1038/36038

実験手法

X-RAY DIFFRACTION (1.85 Å)