1GNG

Glycogen synthase kinase-3 beta (GSK3) complex with FRATtide peptide

1GNG の概要

• エントリーDOI: 10.2210/pdb1gng/pdb
• 関連するPDBエントリー: 1H8F
• 分子名称: GLYCOGEN SYNTHASE KINASE-3 BETA, FRATTIDE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: transferase, protein kinase, gsk3-frattide complex, phosphorylated, active
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Cytoplasm: P49841 Q92837
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95845.22

構造登録者

Bax, B.,Carter, P.S.,Lewis, C.,Guy, A.R.,Bridges, A.,Tanner, R.,Pettman, G.,Mannix, C.,Culbert, A.A.,Brown, M.J.B.,Smith, D.G.,Reith, A.D. (登録日: 2001-10-04, 公開日: 2002-10-03, 最終更新日: 2024-11-06)

主引用文献

Bax, B.,Carter, P.S.,Lewis, C.,Guy, A.R.,Bridges, A.,Tanner, R.,Pettman, G.,Mannix, C.,Culbert, A.A.,Brown, M.J.B.,Smith, D.G.,Reith, A.D.
The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation
Structure, 9:1143-, 2001

PubMed Abstract: Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognizing and phosphorylating the first serine in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine). FRATtide (a peptide derived from a GSK-3 binding protein) binds to GSK-3 and blocks GSK-3 from interacting with Axin. This inhibits the Axin-dependent phosphorylation of beta-catenin by GSK-3.

PubMed: 11738041
DOI: 10.1016/S0969-2126(01)00679-7

実験手法

X-RAY DIFFRACTION (2.6 Å)