1GJ7

ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS

1GJ7 の概要

• エントリーDOI: 10.2210/pdb1gj7/pdb
• 関連するPDBエントリー: 1C5X
• 分子名称: UROKINASE-TYPE PLASMINOGEN ACTIVATOR, CITRIC ACID, 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE, ... (5 entities in total)
• 機能のキーワード: selectivity at s1, h2o displacement, upa, tpa, ser190/ala190 protease, structure-based drug design, blood clotting, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00749 P00749
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31890.69

構造登録者

Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L. (登録日: 2001-04-27, 公開日: 2002-04-27, 最終更新日: 2023-12-27)

• 主引用文献: Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Elrod, K.,Kirtley, M.,Janc, J.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L.; Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.; Chem.Biol., 8:1107-1121, 2001; PubMed: 11731301; DOI: 10.1016/S1074-5521(01)00084-9

実験手法

X-RAY DIFFRACTION (1.5 Å)