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1GJ4

SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN

1GJ4 の概要
エントリーDOI10.2210/pdb1gj4/pdb
関連するPDBエントリー1C5N
分子名称THROMBIN, ACETYL HIRUDIN, SODIUM ION, ... (6 entities in total)
機能のキーワードthree-centered, very short hydrogen bond, oxyanion hole water, shift of pka of his57, structure-based drug design, specificity, urokinase, trypsin, thrombin, zn+2-mediated inhibition, blood clotting, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Secreted, extracellular space: P00734 P00734
Secreted: P28504
タンパク質・核酸の鎖数3
化学式量合計35624.99
構造登録者
Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L. (登録日: 2001-04-27, 公開日: 2002-04-27, 最終更新日: 2023-12-27)
主引用文献Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Elrod, K.,Kirtley, M.,Janc, J.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L.
Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.
Chem.Biol., 8:1107-1121, 2001
Cited by
PubMed: 11731301
DOI: 10.1016/S1074-5521(01)00084-9
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.81 Å)
構造検証レポート
Validation report summary of 1gj4
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

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