1GIO
NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES
Summary for 1GIO
| Entry DOI | 10.2210/pdb1gio/pdb |
| Descriptor | ANGIOGENIN (1 entity in total) |
| Functional Keywords | endoribonuclease, hydrolase angiogenesis |
| Biological source | Bos taurus (cattle) |
| Cellular location | Secreted: P10152 |
| Total number of polymer chains | 1 |
| Total formula weight | 14621.51 |
| Authors | Lequin, O.,Albaret, C.,Bontems, F.,Spik, G.,Lallemand, J.Y. (deposition date: 1996-04-12, release date: 1996-12-07, Last modification date: 2024-10-30) |
| Primary citation | Lequin, O.,Albaret, C.,Bontems, F.,Spik, G.,Lallemand, J.Y. Solution structure of bovine angiogenin by 1H nuclear magnetic resonance spectroscopy. Biochemistry, 35:8870-8880, 1996 Cited by PubMed Abstract: The three-dimensional structure of bovine angiogenin has been determined using two- and three-dimensional proton NMR spectroscopy. The solution structure is very close to that recently determined by X-ray diffraction analysis. This structure appears well defined, even if five loops and one helix exhibit greater flexibility. Analysis of the active site geometry confirms the position of the Glu-118 residue which obstructs the pyrimidine binding site. There is no experimental evidence of an unobstructed conformation of angiogenin in solution. In addition, it appears that the Glu-118 and Ser-119 residues and the cell receptor binding loop may play an important role in the differences of C-terminal fragment organization and ribonucleolytic activity observed between angiogenins and ribonuclease A. PubMed: 8688423DOI: 10.1021/bi960022r PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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