1GGN

Structures of glycogen phosphorylase-inhibitor complexes and the implications for structure-based drug design

1GGN の概要

• エントリーDOI: 10.2210/pdb1ggn/pdb
• 関連するPDBエントリー: 1A8I
• 分子名称: PROTEIN (GLYCOGEN PHOSPHORYLASE), BETA-D-GLUCOPYRANOSE SPIROHYDANTOIN, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: transferase, glycogen phosphorylase, inhibitor complex, catalytic site, design
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97786.54

構造登録者

Watson, K.A.,Tsitsanou, K.E.,Gregoriou, M.,Zographos, S.E.,Skamnaki, V.T.,Oikonomakos, N.G.,Fleet, G.W.,Johnson, L.N. (登録日: 2000-08-29, 公開日: 2000-09-13, 最終更新日: 2023-08-09)

• 主引用文献: Oikonomakos, N.G.,Skamnaki, V.T.,Osz, E.,Szilagyi, L.,Somsak, L.,Docsa, T.,Toth, B.,Gergely, P.; Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B.; Bioorg.Med.Chem., 10:261-268, 2002; PubMed: 11741774; DOI: 10.1016/S0968-0896(01)00277-2

実験手法

X-RAY DIFFRACTION (2.36 Å)