1GGC

MAJOR ANTIGEN-INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY

Summary for 1GGC

• Entry DOI: 10.2210/pdb1ggc/pdb
• Descriptor: IGG2A-KAPPA 50.1 FAB (LIGHT CHAIN), IGG2A-KAPPA 50.1 FAB (HEAVY CHAIN) (2 entities in total)
• Functional Keywords: immunoglobulin
• Biological source: Mus musculus (house mouse); More
• Cellular location: Cell membrane; Single-pass membrane protein (Potential): P01865
• Total number of polymer chains: 2
• Total formula weight: 46777.87

Authors

Takimoto-Kamimura, M.,Wilson, I.A. (deposition date: 1993-07-19, release date: 1993-10-31, Last modification date: 2024-10-23)

Primary citation

Stanfield, R.L.,Takimoto-Kamimura, M.,Rini, J.M.,Profy, A.T.,Wilson, I.A.
Major antigen-induced domain rearrangements in an antibody.
Structure, 1:83-93, 1993

PubMed Abstract: Recent structural results have shown that antibodies use an induced fit mechanism to recognize and bind their antigens. Here we present the crystallographically determined structure of an Fab directed against an HIV-1 peptide (Fab 50.1) in the unliganded state and compare it with the peptide-bound structure. We perform a detailed analysis of the components that contribute to enhanced antigen binding and recognition.

PubMed: 8069628
DOI: 10.1016/0969-2126(93)90024-B

Experimental method

X-RAY DIFFRACTION (2.8 Å)