1GGC

MAJOR ANTIGEN-INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY

1GGC の概要

• エントリーDOI: 10.2210/pdb1ggc/pdb
• 分子名称: IGG2A-KAPPA 50.1 FAB (LIGHT CHAIN), IGG2A-KAPPA 50.1 FAB (HEAVY CHAIN) (2 entities in total)
• 機能のキーワード: immunoglobulin
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Cell membrane; Single-pass membrane protein (Potential): P01865
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46777.87

構造登録者

Takimoto-Kamimura, M.,Wilson, I.A. (登録日: 1993-07-19, 公開日: 1993-10-31, 最終更新日: 2024-10-23)

主引用文献

Stanfield, R.L.,Takimoto-Kamimura, M.,Rini, J.M.,Profy, A.T.,Wilson, I.A.
Major antigen-induced domain rearrangements in an antibody.
Structure, 1:83-93, 1993

PubMed Abstract: Recent structural results have shown that antibodies use an induced fit mechanism to recognize and bind their antigens. Here we present the crystallographically determined structure of an Fab directed against an HIV-1 peptide (Fab 50.1) in the unliganded state and compare it with the peptide-bound structure. We perform a detailed analysis of the components that contribute to enhanced antigen binding and recognition.

PubMed: 8069628
DOI: 10.1016/0969-2126(93)90024-B

実験手法

X-RAY DIFFRACTION (2.8 Å)