1GFD

SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE C-TERMINAL SH3 DOMAIN OF GRB2

1GFD の概要

• エントリーDOI: 10.2210/pdb1gfd/pdb
• 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (1 entity in total)
• 機能のキーワード: adaptor protein containing sh2 and sh3
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P62993
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6785.43

構造登録者

Kohda, D.,Terasawa, H.,Hatanaka, H.,Inagaki, F. (登録日: 1994-06-13, 公開日: 1994-08-31, 最終更新日: 2024-05-01)

主引用文献

Kohda, D.,Terasawa, H.,Ichikawa, S.,Ogura, K.,Hatanaka, H.,Mandiyan, V.,Ullrich, A.,Schlessinger, J.,Inagaki, F.
Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
Structure, 2:1029-1040, 1994

PubMed Abstract: Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein with three Src homology (SH) domains in the order SH3-SH2-SH3. Both SH3 domains of GRB2 are necessary for interaction with the protein Son of sevenless (Sos), which acts as a Ras activator. Thus, GRB2 mediates signal transduction from growth factor receptors to Ras and is thought to be a key molecule in signal transduction.

PubMed: 7881903
DOI: 10.1016/S0969-2126(94)00106-5

実験手法

SOLUTION NMR