1GD5

SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE

1GD5 の概要

• エントリーDOI: 10.2210/pdb1gd5/pdb
• 分子名称: NEUTROPHIL CYTOSOL FACTOR 1 (1 entity in total)
• 機能のキーワード: alpha beta, p47-phox, px domain, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15325.80

構造登録者

Hiroaki, H.,Ago, T.,Ito, T.,Sumimoto, H.,Kohda, D. (登録日: 2000-09-14, 公開日: 2001-06-13, 最終更新日: 2023-12-27)

主引用文献

Hiroaki, H.,Ago, T.,Ito, T.,Sumimoto, H.,Kohda, D.
Solution structure of the PX domain, a target of the SH3 domain.
Nat.Struct.Biol., 8:526-530, 2001

PubMed Abstract: The phox homology (PX) domain is a novel protein module containing a conserved proline-rich motif. We have shown that the PX domain isolated from the human p47phox protein, a soluble subunit of phagocyte NADPH oxidase, binds specifically to the C-terminal SH3 domain derived from the same protein. The solution structure of p47 PX has an alpha + beta structure with a novel folding motif topology and reveals that the proline-rich motif is presented on the molecular surface for easy recognition by the SH3 domain. The proline-rich motif of p47 PX in the free state adopts a distorted left-handed polyproline type II helix conformation.

PubMed: 11373621
DOI: 10.1038/88591

実験手法

SOLUTION NMR