1GCN

X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING

1GCN の概要

• エントリーDOI: 10.2210/pdb1gcn/pdb
• 分子名称: GLUCAGON (1 entity in total)
• 機能のキーワード: hormone
• 由来する生物種: Sus scrofa (pig)
• 細胞内の位置: Secreted: P01274
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3486.78

構造登録者

Blundell, T.L.,Sasaki, K.,Dockerill, S.,Tickle, I.J. (登録日: 1977-10-17, 公開日: 1977-11-28, 最終更新日: 2024-02-07)

主引用文献

Sasaki, K.,Dockerill, S.,Adamiak, D.A.,Tickle, I.J.,Blundell, T.
X-ray analysis of glucagon and its relationship to receptor binding.
Nature, 257:751-757, 1975

PubMed Abstract: X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor.

PubMed: 171582
DOI: 10.1038/257751a0

実験手法

X-RAY DIFFRACTION (3 Å)