1G9P

SOLUTION STRUCTURE OF THE INSECTICIDAL CALCIUM CHANNEL BLOCKER OMEGA-ATRACOTOXIN-HV2A

Summary for 1G9P

• Entry DOI: 10.2210/pdb1g9p/pdb
• NMR Information: BMRB: 4923
• Descriptor: OMEGA-ATRACOTOXIN-HV2A (1 entity in total)
• Functional Keywords: cystine knot, toxin
• Biological source: Hadronyche versuta
• Total number of polymer chains: 1
• Total formula weight: 4488.29

Authors

Wang, X.-H.,King, G.F. (deposition date: 2000-11-27, release date: 2002-02-21, Last modification date: 2024-10-16)

Primary citation

Wang, X.H.,Connor, M.,Wilson, D.,Wilson, H.I.,Nicholson, G.M.,Smith, R.,Shaw, D.,Mackay, J.P.,Alewood, P.F.,Christie, M.J.,King, G.F.
Discovery and structure of a potent and highly specific blocker of insect calcium channels.
J.Biol.Chem., 276:40306-40312, 2001

PubMed Abstract: We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with omega-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities.

PubMed: 11522785

Experimental method

SOLUTION NMR