1G8J

CRYSTAL STRUCTURE ANALYSIS OF ARSENITE OXIDASE FROM ALCALIGENES FAECALIS

Summary for 1G8J

• Entry DOI: 10.2210/pdb1g8j/pdb
• Related: 1G8K
• Descriptor: ARSENITE OXIDASE, 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, OXYGEN ATOM, ... (8 entities in total)
• Functional Keywords: oxidase, arsenite, molybdopterin, [3fe-4s] cluster, [2fe-2s] cluster, rieske, oxidoreductase
• Biological source: Alcaligenes faecalis; More
• Total number of polymer chains: 4
• Total formula weight: 215831.23

Authors

Ellis, P.J.,Conrads, T.,Hille, R.,Kuhn, P. (deposition date: 2000-11-17, release date: 2000-12-13, Last modification date: 2011-07-13)

Primary citation

Ellis, P.J.,Conrads, T.,Hille, R.,Kuhn, P.
Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in two crystal forms at 1.64 A and 2.03 A.
Structure, 9:125-132, 2001

PubMed Abstract: Arsenite oxidase from Alcaligenes faecalis NCIB 8687 is a molybdenum/iron protein involved in the detoxification of arsenic. It is induced by the presence of AsO(2-) (arsenite) and functions to oxidize As(III)O(2-), which binds to essential sulfhydryl groups of proteins and dithiols, to the relatively less toxic As(V)O(4)(3-) (arsenate) prior to methylation.

PubMed: 11250197
DOI: 10.1016/S0969-2126(01)00566-4

Experimental method

X-RAY DIFFRACTION (2.03 Å)