1G6W

CRYSTAL STRUCTURE OF THE GLOBULAR REGION OF THE PRION PROTEIN URE2 FROM THE YEAST SACCAROMYCES CEREVISIAE

1G6W の概要

• エントリーDOI: 10.2210/pdb1g6w/pdb
• 関連するPDBエントリー: 1G6Y
• 分子名称: URE2 PROTEIN (2 entities in total)
• 機能のキーワード: gst superfamily, structural genomics
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 119864.42

構造登録者

Bousset, L.,Belrhali, H.,Janin, J.,Melki, R.,Morera, S. (登録日: 2000-11-08, 公開日: 2001-02-21, 最終更新日: 2024-02-07)

主引用文献

Bousset, L.,Belrhali, H.,Janin, J.,Melki, R.,Morera, S.
Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae.
Structure, 9:39-46, 2001

PubMed Abstract: The [URE3] non-Mendelian element of the yeast S. cerevisiae is due to the propagation of a transmissible form of the protein Ure2. The infectivity of Ure2p is thought to originate from a conformational change of the normal form of the prion protein. This conformational change generates a form of Ure2p that assembles into amyloid fibrils. Hence, knowledge of the three-dimensional structure of prion proteins such as Ure2p should help in understanding the mechanism of amyloid formation associated with a number of neurodegenerative diseases.

PubMed: 11342133
DOI: 10.1016/S0969-2126(00)00553-0

実験手法

X-RAY DIFFRACTION (2.5 Å)