1G65

Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors

Summary for 1G65

• Entry DOI: 10.2210/pdb1g65/pdb
• Related: 1G0U 1PMA 1RYP
• Descriptor: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (17 entities in total)
• Functional Keywords: proteasome, epoxomicin, ubiquitin, ntn-hydolase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 30
• Total formula weight: 705534.79

Authors

Groll, M.,Kim, K.B.,Kairies, N.,Huber, R.,Crews, C. (deposition date: 2000-11-03, release date: 2000-11-27, Last modification date: 2023-11-15)

• Primary citation: Groll, M.,Kim, K.B.,Kairies, N.,Crews, C.; Crystal Structure of Epoxomicin:20S Proteasome reveals a molecular basis for selectivity of alpha,beta-Epoxyketone Proteasome Inhibitors; J.Am.Chem.Soc., 122:1237-1238, 2000; DOI: 10.1021/ja993588m

Experimental method

X-RAY DIFFRACTION (2.25 Å)