1G5S

CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717

1G5S の概要

• エントリーDOI: 10.2210/pdb1g5s/pdb
• 分子名称: CELL DIVISION PROTEIN KINASE 2, 2-[TRANS-(4-AMINOCYCLOHEXYL)AMINO]-6-(BENZYL-AMINO)-9-CYCLOPENTYLPURINE (3 entities in total)
• 機能のキーワード: protein-inhibitor complex, cell cycle-transferase complex, cell cycle/transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34382.03

構造登録者

Dreyer, M.K.,Borcherding, D.R.,Dumont, J.A.,Peet, N.P.,Tsay, J.T.,Wright, P.S.,Bitonti, A.J.,Shen, J.,Kim, S.-H. (登録日: 2000-11-02, 公開日: 2001-11-02, 最終更新日: 2023-08-09)

• 主引用文献: Dreyer, M.K.,Borcherding, D.R.,Dumont, J.A.,Peet, N.P.,Tsay, J.T.,Wright, P.S.,Bitonti, A.J.,Shen, J.,Kim, S.H.; Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717.; J.Med.Chem., 44:524-530, 2001; PubMed: 11170642; DOI: 10.1021/jm001043t

実験手法

X-RAY DIFFRACTION (2.61 Å)