1G5G

FRAGMENT OF FUSION PROTEIN FROM NEWCASTLE DISEASE VIRUS

Summary for 1G5G

• Entry DOI: 10.2210/pdb1g5g/pdb
• Descriptor: Fusion glycoprotein F0, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: fusion protein, ndv, newcastle disease virus, paramyxovirus, viral protein
• Biological source: Avian orthoavulavirus 1
• Cellular location: Virion membrane ; Single-pass type I membrane protein : A9LSB1
• Total number of polymer chains: 6
• Total formula weight: 310963.41

Authors

Lawrence, M.C.,Smith, B.J. (deposition date: 2000-11-01, release date: 2002-02-27, Last modification date: 2024-11-20)

Primary citation

Chen, L.,Gorman, J.J.,McKimm-Breschkin, J.,Lawrence, L.J.,Tulloch, P.A.,Smith, B.J.,Colman, P.M.,Lawrence, M.C.
The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion.
Structure, 9:255-266, 2001

PubMed Abstract: Membrane fusion within the Paramyxoviridae family of viruses is mediated by a surface glycoprotein termed the "F", or fusion, protein. Membrane fusion is assumed to involve a series of structural transitions of F from a metastable (prefusion) state to a highly stable (postfusion) state. No detail is available at the atomic level regarding the metastable form of these proteins or regarding the transitions accompanying fusion.

PubMed: 11286892
DOI: 10.1016/S0969-2126(01)00581-0

Experimental method

X-RAY DIFFRACTION (3.3 Å)