1G5G

FRAGMENT OF FUSION PROTEIN FROM NEWCASTLE DISEASE VIRUS

1G5G の概要

• エントリーDOI: 10.2210/pdb1g5g/pdb
• 分子名称: Fusion glycoprotein F0, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: fusion protein, ndv, newcastle disease virus, paramyxovirus, viral protein
• 由来する生物種: Avian orthoavulavirus 1
• 細胞内の位置: Virion membrane ; Single-pass type I membrane protein : A9LSB1
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 310963.41

構造登録者

Lawrence, M.C.,Smith, B.J. (登録日: 2000-11-01, 公開日: 2002-02-27, 最終更新日: 2024-11-20)

主引用文献

Chen, L.,Gorman, J.J.,McKimm-Breschkin, J.,Lawrence, L.J.,Tulloch, P.A.,Smith, B.J.,Colman, P.M.,Lawrence, M.C.
The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion.
Structure, 9:255-266, 2001

PubMed Abstract: Membrane fusion within the Paramyxoviridae family of viruses is mediated by a surface glycoprotein termed the "F", or fusion, protein. Membrane fusion is assumed to involve a series of structural transitions of F from a metastable (prefusion) state to a highly stable (postfusion) state. No detail is available at the atomic level regarding the metastable form of these proteins or regarding the transitions accompanying fusion.

PubMed: 11286892
DOI: 10.1016/S0969-2126(01)00581-0

実験手法

X-RAY DIFFRACTION (3.3 Å)