1G3J
CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX
Summary for 1G3J
| Entry DOI | 10.2210/pdb1g3j/pdb |
| Descriptor | BETA-CATENIN ARMADILLO REPEAT REGION, TCF3-CBD (CATENIN BINDING DOMAIN) (3 entities in total) |
| Functional Keywords | beta-catenin, tcf-3, protein-protein complex, transcription |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm: P35222 P70062 |
| Total number of polymer chains | 4 |
| Total formula weight | 128993.80 |
| Authors | Graham, T.A.,Weaver, C.,Mao, F.,Kimelman, D.,Xu, W. (deposition date: 2000-10-24, release date: 2000-12-11, Last modification date: 2024-02-07) |
| Primary citation | Graham, T.A.,Weaver, C.,Mao, F.,Kimelman, D.,Xu, W. Crystal structure of a beta-catenin/Tcf complex. Cell(Cambridge,Mass.), 103:885-896, 2000 Cited by PubMed Abstract: The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies. PubMed: 11136974DOI: 10.1016/S0092-8674(00)00192-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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