1G1C

I1 DOMAIN FROM TITIN

1G1C の概要

• エントリーDOI: 10.2210/pdb1g1c/pdb
• 分子名称: IMMUNOGLOBULIN-LIKE DOMAIN I1 FROM TITIN (2 entities in total)
• 機能のキーワード: immunoglobulin domain, beta-sandwhich, i-set, structural protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22479.36

構造登録者

Mayans, O.,Wuerges, J.,Gautel, M.,Wilmanns, M. (登録日: 2000-10-11, 公開日: 2001-10-12, 最終更新日: 2024-10-30)

主引用文献

Mayans, O.,Wuerges, J.,Canela, S.,Gautel, M.,Wilmanns, M.
Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin.
Structure, 9:331-340, 2001

PubMed Abstract: The giant muscle protein titin contributes to the filament system in skeletal and cardiac muscle cells by connecting the Z disk and the central M line of the sarcomere. One of the physiological functions of titin is to act as a passive spring in the sarcomere, which is achieved by the elastic properties of its central I band region. Titin contains about 300 domains of which more than half are folded as immunoglobulin-like (Ig) domains. Ig domain segments of the I band of titin have been extensively used as templates to investigate the molecular basis of protein elasticity.

PubMed: 11525170
DOI: 10.1016/s0969-2126(01)00591-3

実験手法

X-RAY DIFFRACTION (2.1 Å)