1FYY

HPRT GENE MUTATION HOTSPOT WITH A BPDE2(10R) ADDUCT

Summary for 1FYY

• Entry DOI: 10.2210/pdb1fyy/pdb
• NMR Information: BMRB: 4647
• Descriptor: HPRT DNA WITH BENZO[A]PYRENE-ADDUCTED DA7, 5'-D(*TP*GP*CP*CP*CP*TP*TP*GP*AP*CP*TP*A)-3', 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE (3 entities in total)
• Functional Keywords: dna lesions, benzo[a]pyrene, hprt gene, diol epoxide adducts, syn-anti interconversion, dna
• Total number of polymer chains: 2
• Total formula weight: 7629.15

Authors

Volk, D.E.,Rice, J.S.,Luxon, B.A.,Yeh, H.J.C.,Liang, C.,Xie, G.,Sayer, J.M.,Jerina, D.M.,Gorenstein, D.G. (deposition date: 2000-10-03, release date: 2000-12-06, Last modification date: 2022-02-23)

• Primary citation: Volk, D.E.,Rice, J.S.,Luxon, B.A.,Yeh, H.J.,Liang, C.,Xie, G.,Sayer, J.M.,Jerina, D.M.,Gorenstein, D.G.; NMR evidence for syn-anti interconversion of a trans opened (10R)-dA adduct of benzo[a]pyrene (7S,8R)-diol (9R,10S)-epoxide in a DNA duplex.; Biochemistry, 39:14040-14053, 2000; PubMed: 11087351; DOI: 10.1021/bi001669l

Experimental method

SOLUTION NMR