1FYC

INNER LIPOYL DOMAIN FROM HUMAN PYRUVATE DEHYDROGENASE (PDH) COMPLEX, NMR, 1 STRUCTURE

1FYC の概要

• エントリーDOI: 10.2210/pdb1fyc/pdb
• 分子名称: DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2P) (1 entity in total)
• 機能のキーワード: transferase, acyltransferase dihydrolipoamide, subunit, unlipoylated
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion matrix: P10515
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11661.32

構造登録者

Howard, M.J.,Fuller, C.,Broadhurst, R.W.,Quinn, J.,Yeaman, S.J.,Perham, R.N. (登録日: 1997-02-21, 公開日: 1997-09-04, 最終更新日: 2024-05-01)

主引用文献

Howard, M.J.,Fuller, C.,Broadhurst, R.W.,Perham, R.N.,Tang, J.G.,Quinn, J.,Diamond, A.G.,Yeaman, S.J.
Three-dimensional structure of the major autoantigen in primary biliary cirrhosis.
Gastroenterology, 115:139-146, 1998

PubMed Abstract: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients' serum. The major autoantigen, recognized by antibodies from > 95% of patients with PBC, has been identified as the E2 component (E2p) of the pyruvate dehydrogenase multienzyme complex. Immunodominant sites on E2p have been localized to the inner of the two lipoyl domains, where the essential cofactor lipoic acid is attached covalently. The aim of this study was to determine the three-dimensional structure of the inner lipoyl domain of human E2p.

PubMed: 9649469

実験手法

SOLUTION NMR