1FX3

CRYSTAL STRUCTURE OF H. INFLUENZAE SECB

1FX3 の概要

• エントリーDOI: 10.2210/pdb1fx3/pdb
• 分子名称: PROTEIN-EXPORT PROTEIN SECB (2 entities in total)
• 機能のキーワード: protein trasnport, translocation, transport protein
• 由来する生物種: Haemophilus influenzae
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 76585.20

構造登録者

Xu, Z.,Knafels, J.D.,Yoshino, K. (登録日: 2000-09-25, 公開日: 2000-12-06, 最終更新日: 2024-02-07)

主引用文献

Xu, Z.,Knafels, J.D.,Yoshino, K.
Crystal structure of the bacterial protein export chaperone secB.
Nat.Struct.Biol., 7:1172-1177, 2000

PubMed Abstract: SecB is a bacterial molecular chaperone involved in mediating translocation of newly synthesized polypeptides across the cytoplasmic membrane of bacteria. The crystal structure of SecB from Haemophilus influenzae shows that the molecule is a tetramer organized as a dimer of dimers. Two long channels run along the side of the molecule. These are bounded by flexible loops and lined with conserved hydrophobic amino acids, which define a suitable environment for binding non-native polypeptides. The structure also reveals an acidic region on the top surface of the molecule, several residues of which have been implicated in binding to SecA, its downstream target.

PubMed: 11101901
DOI: 10.1038/82040

実験手法

X-RAY DIFFRACTION (2.5 Å)