1FWL

CRYSTAL STRUCTURE OF HOMOSERINE KINASE

1FWL の概要

• エントリーDOI: 10.2210/pdb1fwl/pdb
• 関連するPDBエントリー: 1FWK
• 分子名称: HOMOSERINE KINASE (2 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Methanocaldococcus jannaschii
• 細胞内の位置: Cytoplasm (Potential): Q58504
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 129197.48

構造登録者

Zhou, T.,Daugherty, M.,Grishin, N.V.,Osterman, A.L.,Zhang, H. (登録日: 2000-09-22, 公開日: 2000-12-20, 最終更新日: 2024-02-07)

主引用文献

Zhou, T.,Daugherty, M.,Grishin, N.V.,Osterman, A.L.,Zhang, H.
Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8:1247-1257, 2000

PubMed Abstract: Homoserine kinase (HSK) catalyzes an important step in the threonine biosynthesis pathway. It belongs to a large yet unique class of small metabolite kinases, the GHMP kinase superfamily. Members in the GHMP superfamily participate in several essential metabolic pathways, such as amino acid biosynthesis, galactose metabolism, and the mevalonate pathway.

PubMed: 11188689
DOI: 10.1016/S0969-2126(00)00533-5

実験手法

X-RAY DIFFRACTION (2.25 Å)