1FTD
5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'-SYMMETRIC BIS-BENZIMIDAZOLE COMPLEX
Summary for 1FTD
Entry DOI | 10.2210/pdb1ftd/pdb |
Descriptor | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, [3-(4-{2'-[4-(3-DIMETHYLAMINO-PROPOXY)-PHENYL]-3H,3'H-[5,5']BIBENZOIMIDAZOLYL-2-YL}-PHENOXY)-PROPYL]-DIMETHYL-AMINE, ... (4 entities in total) |
Functional Keywords | minor groove binding, dna |
Total number of polymer chains | 2 |
Total formula weight | 7939.83 |
Authors | Mann, J.,Baron, A.,Opoku-Boahen, Y.,Johansson, E.,Parkinson, G.,Kelland, L.R.,Neidle, S. (deposition date: 2000-09-12, release date: 2001-02-26, Last modification date: 2024-02-07) |
Primary citation | Mann, J.,Baron, A.,Opoku-Boahen, Y.,Johansson, E.,Parkinson, G.,Kelland, L.R.,Neidle, S. A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity. J.Med.Chem., 44:138-144, 2001 Cited by PubMed: 11170623DOI: 10.1021/jm000297b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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