1FT4

PHOTOCHEMICALLY-ENHANCED BINDING OF SMALL MOLECULES TO THE TUMOR NECROSIS FACTOR RECEPTOR-1

Summary for 1FT4

• Entry DOI: 10.2210/pdb1ft4/pdb
• Related: 1NCF
• Descriptor: SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1, 5-(3-MORPHOLIN-4-YL-PROPYL)-2-(3-NITRO-PHENYL)-4-THIOXO-4,5-DIHYDRO-1-THIA-3B,5-DIAZA-CYCLOPENTA[A]PENTALEN-6-ONE (2 entities in total)
• Functional Keywords: binding protein, cytokine, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein . Isoform 4: Secreted: P19438
• Total number of polymer chains: 2
• Total formula weight: 37128.20

Authors

Muckelbauer, J.K.,Chang, C.-H. (deposition date: 2000-09-11, release date: 2001-10-12, Last modification date: 2017-10-04)

• Primary citation: Carter, P.H.,Scherle, P.A.,Muckelbauer, J.K.,Voss, M.E.,Liu, R.Q.,Thompson, L.A.,Tebben, A.J.,Solomon, K.A.,Lo, Y.C.,Li, Z.,Strzemienski, P.,Yang, G.,Falahatpisheh, N.,Xu, M.,Wu, Z.,Farrow, N.A.,Ramnarayan, K.,Wang, J.,Rideout, D.,Yalamoori, V.,Domaille, P.,Underwood, D.J.,Trzaskos, J.M.,Friedman, S.M.,Newton, R.C.,Decicco, C.P.,Muckelbauer, J.A.; Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.; Proc.Natl.Acad.Sci.USA, 98:11879-11884, 2001; PubMed: 11592999; DOI: 10.1073/pnas.211178398

Experimental method

X-RAY DIFFRACTION (2.9 Å)