1FT4

PHOTOCHEMICALLY-ENHANCED BINDING OF SMALL MOLECULES TO THE TUMOR NECROSIS FACTOR RECEPTOR-1

1FT4 の概要

• エントリーDOI: 10.2210/pdb1ft4/pdb
• 関連するPDBエントリー: 1NCF
• 分子名称: SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1, 5-(3-MORPHOLIN-4-YL-PROPYL)-2-(3-NITRO-PHENYL)-4-THIOXO-4,5-DIHYDRO-1-THIA-3B,5-DIAZA-CYCLOPENTA[A]PENTALEN-6-ONE (2 entities in total)
• 機能のキーワード: binding protein, cytokine, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein . Isoform 4: Secreted: P19438
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37128.20

構造登録者

Muckelbauer, J.K.,Chang, C.-H. (登録日: 2000-09-11, 公開日: 2001-10-12, 最終更新日: 2017-10-04)

• 主引用文献: Carter, P.H.,Scherle, P.A.,Muckelbauer, J.K.,Voss, M.E.,Liu, R.Q.,Thompson, L.A.,Tebben, A.J.,Solomon, K.A.,Lo, Y.C.,Li, Z.,Strzemienski, P.,Yang, G.,Falahatpisheh, N.,Xu, M.,Wu, Z.,Farrow, N.A.,Ramnarayan, K.,Wang, J.,Rideout, D.,Yalamoori, V.,Domaille, P.,Underwood, D.J.,Trzaskos, J.M.,Friedman, S.M.,Newton, R.C.,Decicco, C.P.,Muckelbauer, J.A.; Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.; Proc.Natl.Acad.Sci.USA, 98:11879-11884, 2001; PubMed: 11592999; DOI: 10.1073/pnas.211178398

実験手法

X-RAY DIFFRACTION (2.9 Å)