1FQX

CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR

1FQX の概要

• エントリーDOI: 10.2210/pdb1fqx/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000386
• 分子名称: PROTEASE RETROPEPSIN, N-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide (3 entities in total)
• 機能のキーワード: aspartyl protease, protease, hiv, peptidomimetic, inhibitor, drug design, hydroxyethylamine isostere, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22311.34

構造登録者

Dohnalek, J.,Hasek, J.,Duskova, J.,Petrokova, H.,Hradilek, M.,Soucek, M.,Konvalinka, J.,Brynda, J.,Sedlacek, J.,Fabry, M. (登録日: 2000-09-07, 公開日: 2001-03-14, 最終更新日: 2024-02-07)

• 主引用文献: Dohnalek, J.,Hasek, J.,Duskova, J.,Petrokova, H.,Hradilek, M.,Soucek, M.,Konvalinka, J.,Brynda, J.,Sedlacek, J.,Fabry, M.; A distinct binding mode of a hydroxyethylamine isostere inhibitor of HIV-1 protease.; Acta Crystallogr.,Sect.D, 57:472-476, 2001; PubMed: 11223536; DOI: 10.1107/S0907444900018928

実験手法

X-RAY DIFFRACTION (3.1 Å)