1FMK

CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC

1FMK の概要

• エントリーDOI: 10.2210/pdb1fmk/pdb
• 分子名称: TYROSINE-PROTEIN KINASE SRC (2 entities in total)
• 機能のキーワード: src, tyrosine kinase, phosphorylation, sh2, sh3, phosphotyrosine, proto-oncogene, phosphotransferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane: P12931
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51709.57

構造登録者

Xu, W.,Harrison, S.C.,Eck, M.J. (登録日: 1997-01-24, 公開日: 1997-08-20, 最終更新日: 2024-10-09)

主引用文献

Xu, W.,Harrison, S.C.,Eck, M.J.
Three-dimensional structure of the tyrosine kinase c-Src.
Nature, 385:595-602, 1997

PubMed Abstract: The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and kinase domains and the carboxy-terminal tall, has been determined at 1.7 A resolution in a closed, inactive state. Interactions among domains, stabilized by binding of the phosphorylated tail to the SH2 domain, lock the molecule in a conformation that simultaneously disrupts the kinase active site and sequesters the binding surfaces of the SH2 and SH3 domains. The structure shows how appropriate cellular signals, or transforming mutations in v-Src, could break these interactions to produce an open, active kinase.

PubMed: 9024657
DOI: 10.1038/385595a0

実験手法

X-RAY DIFFRACTION (1.5 Å)