1FKI

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12

Summary for 1FKI

• Entry DOI: 10.2210/pdb1fki/pdb
• Descriptor: FK506 BINDING PROTEIN, (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE (3 entities in total)
• Functional Keywords: cis-trans isomerase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytosol : P62942
• Total number of polymer chains: 2
• Total formula weight: 24548.16

Authors

Holt, D.A.,Luengo, J.I.,Yamashita, D.S.,Oh, H.-J.,Konialian, A.L.,Yen, H.-K.,Rozamus, L.W.,Brandt, M.,Bossard, M.J.,Levy, M.A.,Eggleston, D.S.,Stout, T.J.,Liang, J.,Schultz, L.W.,Clardy, J. (deposition date: 1993-08-05, release date: 1994-01-31, Last modification date: 2024-02-07)

• Primary citation: Holt, D.A.,Luengo, J.I.,Yamashita, D.S.,Oh, H.J.,Konialian, A.L.,Yen, H.K.,Rozamus, L.W.,Brandt, M.,Bossard, M.J.,Levy, M.A.,Eggleston, D.S.,Liang, J.,Schultz, L.W.,Stout, T.J.,Clardy, J.; DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.; J.Am.Chem.Soc., 115:9925-9938, 1993

Experimental method

X-RAY DIFFRACTION (2.2 Å)