1FJ5

TAMOXIFEN-DNA ADDUCT

Summary for 1FJ5

• Entry DOI: 10.2210/pdb1fj5/pdb
• Descriptor: DNA (5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3'), (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINIUM (3 entities in total)
• Functional Keywords: covalent dna-tamoxifen complex; groove binding; localized helical perturbation; widened minor groove, dna
• Total number of polymer chains: 2
• Total formula weight: 7080.92

Authors

Shimotakahara, S.,Gorin, A.,Kolbanovskiy, A.,Kettani, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.,Patel, D.J. (deposition date: 2000-08-07, release date: 2000-09-11, Last modification date: 2022-02-23)

• Primary citation: Shimotakahara, S.,Gorin, A.,Kolbanovskiy, A.,Kettani, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.,Patel, D.J.; Accomodation of S-cis-tamoxifen-N(2)-guanine adduct within a bent and widened DNA minor groove.; J.Mol.Biol., 302:377-393, 2000; PubMed: 10970740; DOI: 10.1006/jmbi.2000.4071

Experimental method

SOLUTION NMR