1FIW

THREE-DIMENSIONAL STRUCTURE OF BETA-ACROSIN FROM RAM SPERMATOZOA

1FIW の概要

• エントリーDOI: 10.2210/pdb1fiw/pdb
• 関連するPDBエントリー: 1FIZ
• 分子名称: BETA-ACROSIN HEAVY CHAIN, BETA-ACROSIN LIGHT CHAIN, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: anti-parallel beta-barrel, hydrolase
• 由来する生物種: Ovis aries (sheep); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35610.43

構造登録者

Tranter, R.,Read, J.A.,Jones, R.,Brady, R.L. (登録日: 2000-08-07, 公開日: 2000-11-08, 最終更新日: 2024-10-09)

主引用文献

Tranter, R.,Read, J.A.,Jones, R.,Brady, R.L.
Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.
Structure Fold.Des., 8:1179-1188, 2000

PubMed Abstract: Proacrosin is a serine protease found specifically within the acrosomal vesicle of all mammalian spermatozoa. During fertilization proacrosin autoactivates to form beta-acrosin, in which there is a "light" chain cross-linked to a "heavy" chain by two disulphide bonds. beta-acrosin is thought to be multifunctional with roles in acrosomal exocytosis, as a receptor for zona pellucida proteins, and as a protease to facilitate penetration of spermatozoa into the egg.

PubMed: 11080640
DOI: 10.1016/S0969-2126(00)00523-2

実験手法

X-RAY DIFFRACTION (2.1 Å)