1FIV

STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS

1FIV の概要

• エントリーDOI: 10.2210/pdb1fiv/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000427
• 分子名称: FIV PROTEASE, FIV PROTEASE INHIBITOR ACE-ALN-VAL-STA-GLU-ALN-NH2 (3 entities in total)
• 機能のキーワード: acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Feline immunodeficiency virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 13664.81

構造登録者

Wlodawer, A.,Gustchina, A.,Reshetnikova, L.,Lubkowski, J.,Zdanov, A. (登録日: 1995-05-04, 公開日: 1995-07-31, 最終更新日: 2025-03-26)

主引用文献

Wlodawer, A.,Gustchina, A.,Reshetnikova, L.,Lubkowski, J.,Zdanov, A.,Hui, K.Y.,Angleton, E.L.,Farmerie, W.G.,Goodenow, M.M.,Bhatt, D.
Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus.
Nat.Struct.Biol., 2:480-488, 1995

PubMed Abstract: The crystal structure of a recombinant form of the proteinase encoded by the feline immunodeficiency virus (FIV PR) has been solved at 2 A resolution and refined to an R-factor of 0.148. The refined structure includes a peptidomimetic, statine-based inhibitor, LP-149, which is an even more potent inhibitor of HIV PR. Kinetic parameters were obtained for the cleavage of five substrates by FIV PR, and inhibition constants were measured for four inhibitors. The structure of FIV PR resembles other related retroviral enzymes although few inhibitors of HIV PR are capable of inhibiting FIV PR. The structure of FIV PR will enhance our knowledge of this class of enzymes, and will direct testing of new proteinase inhibitors in a feline animal model.

PubMed: 7664111
DOI: 10.1038/nsb0695-480

実験手法

X-RAY DIFFRACTION (2 Å)