1FIC

STRUCTURE OF HUMAN GAMMA FIBRINOGEN 30 KD CARBOXYL TERMINAL FRAGMENT

1FIC の概要

• エントリーDOI: 10.2210/pdb1fic/pdb
• 分子名称: GAMMA FIBRINOGEN, CALCIUM ION (3 entities in total)
• 機能のキーワード: blood coagulation, glycoprotein, calcium, platelet, plasma, alternative splicing, disease mutation, polymorphism, blood coagulation factor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02679
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60567.00

構造登録者

Yee, V.C.,Teller, D.C. (登録日: 1996-08-24, 公開日: 1997-04-01, 最終更新日: 2024-11-06)

主引用文献

Yee, V.C.,Pratt, K.P.,Cote, H.C.,Trong, I.L.,Chung, D.W.,Davie, E.W.,Stenkamp, R.E.,Teller, D.C.
Crystal structure of a 30 kDa C-terminal fragment from the gamma chain of human fibrinogen.
Structure, 5:125-138, 1997

PubMed Abstract: Blood coagulation occurs by a cascade of zymogen activation resulting from minor proteolysis. The final stage of coagulation involves thrombin generation and limited proteolysis of fibrinogen to give spontaneously polymerizing fibrin. The resulting fibrin network is covalently crosslinked by factor XIIIa to yield a stable blood clot. Fibrinogen is a 340 kDa glycoprotein composed of six polypeptide chains, (alphabetagamma)2, held together by 29 disulfide bonds. The globular C terminus of the gamma chain contains a fibrin-polymerization surface, the principal factor XIIIa crosslinking site, the platelet receptor recognition site, and a calcium-binding site. Structural information on this domain should thus prove helpful in understanding clot formation.

PubMed: 9016719
DOI: 10.1016/S0969-2126(97)00171-8

実験手法

X-RAY DIFFRACTION (2.5 Å)