1FGL

Cyclophilin A complexed with a fragment of HIV-1 GAG protein

1FGL の概要

• エントリーDOI: 10.2210/pdb1fgl/pdb
• 分子名称: CYCLOPHILIN A, HIV-1 GAG PROTEIN (3 entities in total)
• 機能のキーワード: cyclophilin, binding protein for cyclosporin a, aids, isomerase-peptide complex, isomerase-viral protein complex, isomerase/viral protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm : P62937; Gag polyprotein: Host cell membrane ; Lipid-anchor . Matrix protein p17: Virion membrane ; Lipid-anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion : P05889
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20659.42

構造登録者

Zhao, Y.,Chen, Y.,Schutkowski, M.,Fischer, G.,Ke, H. (登録日: 1996-11-18, 公開日: 1997-04-01, 最終更新日: 2024-10-23)

主引用文献

Zhao, Y.,Chen, Y.,Schutkowski, M.,Fischer, G.,Ke, H.
Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity.
Structure, 5:139-146, 1997

PubMed Abstract: Cyclophilin A (CyPA), a receptor of the immunosuppressive drug cyclosporin A, catalyzes the cis-trans isomerization of peptidyl-prolyl bonds and is required for the infectious activity of human immunodeficiency virus type 1 (HIV-1). The crystal structure of CyPA complexed with a fragment of the HIV-1 gag protein should provide insights into the nature of CyPA-gag interactions and may suggest a role for CyPA in HIV-1 infectious activity.

PubMed: 9016720
DOI: 10.1016/S0969-2126(97)00172-X

実験手法

X-RAY DIFFRACTION (1.8 Å)