1FF9

APO SACCHAROPINE REDUCTASE

Summary for 1FF9

• Entry DOI: 10.2210/pdb1ff9/pdb
• Descriptor: SACCHAROPINE REDUCTASE, SULFATE ION (3 entities in total)
• Functional Keywords: lysine biosynthesis, alpha-aminoadipate pathway, saccharopine reductase, dehydrogenase, oxidoreductase
• Biological source: Magnaporthe grisea
• Total number of polymer chains: 1
• Total formula weight: 49444.45

Authors

Johansson, E.,Steffens, J.J.,Lindqvist, Y.,Schneider, G. (deposition date: 2000-07-25, release date: 2000-11-08, Last modification date: 2024-02-07)

Primary citation

Johansson, E.,Steffens, J.J.,Lindqvist, Y.,Schneider, G.
Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis.
Structure Fold.Des., 8:1037-1047, 2000

PubMed Abstract: The biosynthesis of the essential amino acid lysine in higher fungi and cyanobacteria occurs via the alpha-aminoadipate pathway, which is completely different from the lysine biosynthetic pathway found in plants and bacteria. The penultimate reaction in the alpha-aminoadipate pathway is catalysed by NADPH-dependent saccharopine reductase. We set out to determine the structure of this enzyme as a first step in exploring the structural biology of fungal lysine biosynthesis.

PubMed: 11080625
DOI: 10.1016/S0969-2126(00)00512-8

Experimental method

X-RAY DIFFRACTION (2 Å)