1FF9

APO SACCHAROPINE REDUCTASE

1FF9 の概要

• エントリーDOI: 10.2210/pdb1ff9/pdb
• 分子名称: SACCHAROPINE REDUCTASE, SULFATE ION (3 entities in total)
• 機能のキーワード: lysine biosynthesis, alpha-aminoadipate pathway, saccharopine reductase, dehydrogenase, oxidoreductase
• 由来する生物種: Magnaporthe grisea
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49444.45

構造登録者

Johansson, E.,Steffens, J.J.,Lindqvist, Y.,Schneider, G. (登録日: 2000-07-25, 公開日: 2000-11-08, 最終更新日: 2024-02-07)

主引用文献

Johansson, E.,Steffens, J.J.,Lindqvist, Y.,Schneider, G.
Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis.
Structure Fold.Des., 8:1037-1047, 2000

PubMed Abstract: The biosynthesis of the essential amino acid lysine in higher fungi and cyanobacteria occurs via the alpha-aminoadipate pathway, which is completely different from the lysine biosynthetic pathway found in plants and bacteria. The penultimate reaction in the alpha-aminoadipate pathway is catalysed by NADPH-dependent saccharopine reductase. We set out to determine the structure of this enzyme as a first step in exploring the structural biology of fungal lysine biosynthesis.

PubMed: 11080625
DOI: 10.1016/S0969-2126(00)00512-8

実験手法

X-RAY DIFFRACTION (2 Å)