1FB7

CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE

1FB7 の概要

• エントリーDOI: 10.2210/pdb1fb7/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
• 機能のキーワード: hiv protease, mutant, drug resistance, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11520.69

構造登録者

Hong, L.,Zhang, X.C.,Hartsuck, J.A.,Tang, J. (登録日: 2000-07-14, 公開日: 2000-12-13, 最終更新日: 2024-02-07)

• 主引用文献: Hong, L.,Zhang, X.C.,Hartsuck, J.A.,Tang, J.; Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance.; Protein Sci., 9:1898-1904, 2000; PubMed: 11106162

実験手法

X-RAY DIFFRACTION (2.6 Å)