1F8G

THE X-RAY STRUCTURE OF NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE FROM RHODOSPIRILLUM RUBRUM COMPLEXED WITH NAD+

Summary for 1F8G

Entry DOI	10.2210/pdb1f8g/pdb
Descriptor	NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
Functional Keywords	nucleotide fold, proton pump transhydrogenase, rossmann fold, oxidoreductase
Biological source	Rhodospirillum rubrum
Total number of polymer chains	4
Total formula weight	166766.51
Authors	Buckley, P.A.,Baz Jackson, J.,Schneider, T.,White, S.A.,Rice, D.W.,Baker, P.J. (deposition date: 2000-06-30, release date: 2001-06-30, Last modification date: 2024-10-16)
Primary citation	Buckley, P.A.,Baz Jackson, J.,Schneider, T.,White, S.A.,Rice, D.W.,Baker, P.J. Protein-protein recognition, hydride transfer and proton pumping in the transhydrogenase complex. Structure Fold.Des., 8:809-815, 2000 Cited by PubMed Abstract: Membrane-bound ion pumps are involved in metabolic regulation, osmoregulation, cell signalling, nerve transmission and energy transduction. How the ion electrochemical gradient interacts with the scalar chemistry and how the catalytic machinery is gated to ensure high coupling efficiency are fundamental to the mechanism of action of such pumps. Transhydrogenase is a conformationally coupled proton pump linking a proton gradient to the redox reaction between NAD(H) and NADP(H). The enzyme has three components; dI binds NAD(H), dII spans the membrane and dIII binds NADP(H). PubMed: 10997900 DOI: 10.1016/S0969-2126(00)00171-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation