1F8G

THE X-RAY STRUCTURE OF NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE FROM RHODOSPIRILLUM RUBRUM COMPLEXED WITH NAD+

1F8G の概要

• エントリーDOI: 10.2210/pdb1f8g/pdb
• 分子名称: NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: nucleotide fold, proton pump transhydrogenase, rossmann fold, oxidoreductase
• 由来する生物種: Rhodospirillum rubrum
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 166766.51

構造登録者

Buckley, P.A.,Baz Jackson, J.,Schneider, T.,White, S.A.,Rice, D.W.,Baker, P.J. (登録日: 2000-06-30, 公開日: 2001-06-30, 最終更新日: 2024-10-16)

主引用文献

Buckley, P.A.,Baz Jackson, J.,Schneider, T.,White, S.A.,Rice, D.W.,Baker, P.J.
Protein-protein recognition, hydride transfer and proton pumping in the transhydrogenase complex.
Structure Fold.Des., 8:809-815, 2000

PubMed Abstract: Membrane-bound ion pumps are involved in metabolic regulation, osmoregulation, cell signalling, nerve transmission and energy transduction. How the ion electrochemical gradient interacts with the scalar chemistry and how the catalytic machinery is gated to ensure high coupling efficiency are fundamental to the mechanism of action of such pumps. Transhydrogenase is a conformationally coupled proton pump linking a proton gradient to the redox reaction between NAD(H) and NADP(H). The enzyme has three components; dI binds NAD(H), dII spans the membrane and dIII binds NADP(H).

PubMed: 10997900
DOI: 10.1016/S0969-2126(00)00171-4

実験手法

X-RAY DIFFRACTION (2 Å)