1F62
WSTF-PHD
Summary for 1F62
| Entry DOI | 10.2210/pdb1f62/pdb |
| Descriptor | TRANSCRIPTION FACTOR WSTF, ZINC ION (2 entities in total) |
| Functional Keywords | zn-finger, transcription |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 5953.62 |
| Authors | Pascual, J.,Martinez-Yamout, M.,Dyson, H.J.,Wright, P.E. (deposition date: 2000-06-19, release date: 2000-12-27, Last modification date: 2024-05-01) |
| Primary citation | Pascual, J.,Martinez-Yamout, M.,Dyson, H.J.,Wright, P.E. Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor. J.Mol.Biol., 304:723-729, 2000 Cited by PubMed Abstract: The PHD (plant homeo domain) is a approximately 50-residue motif found mainly in proteins involved in eukaryotic transcription regulation. The characteristic sequence feature is a conserved Cys(4)-HisCys(3) zinc binding motif. We have determined the solution structure of the PHD motif from the human Williams-Beuren syndrome transcription factor (WSTF) protein. The domain folds into an interleaved zinc finger which binds two Zn(2+) in a similar manner to that of the RING and FYVE domains. The structure reveals a conserved zinc-binding core, together with two variable loops that are likely candidates for interactions between the various PHD domains and their specific ligands. PubMed: 11124022DOI: 10.1006/jmbi.2000.4113 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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