1F62

WSTF-PHD

1F62 の概要

• エントリーDOI: 10.2210/pdb1f62/pdb
• 分子名称: TRANSCRIPTION FACTOR WSTF, ZINC ION (2 entities in total)
• 機能のキーワード: zn-finger, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 5953.62

構造登録者

Pascual, J.,Martinez-Yamout, M.,Dyson, H.J.,Wright, P.E. (登録日: 2000-06-19, 公開日: 2000-12-27, 最終更新日: 2024-05-01)

主引用文献

Pascual, J.,Martinez-Yamout, M.,Dyson, H.J.,Wright, P.E.
Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor.
J.Mol.Biol., 304:723-729, 2000

PubMed Abstract: The PHD (plant homeo domain) is a approximately 50-residue motif found mainly in proteins involved in eukaryotic transcription regulation. The characteristic sequence feature is a conserved Cys(4)-HisCys(3) zinc binding motif. We have determined the solution structure of the PHD motif from the human Williams-Beuren syndrome transcription factor (WSTF) protein. The domain folds into an interleaved zinc finger which binds two Zn(2+) in a similar manner to that of the RING and FYVE domains. The structure reveals a conserved zinc-binding core, together with two variable loops that are likely candidates for interactions between the various PHD domains and their specific ligands.

PubMed: 11124022
DOI: 10.1006/jmbi.2000.4113

実験手法

SOLUTION NMR