1F58

IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 24-RESIDUE PEPTIDE (RESIDUES 308-333 OF HIV-1 GP120 (MN ISOLATE) WITH ALA TO AIB SUBSTITUTION AT POSITION 323

1F58 の概要

• エントリーDOI: 10.2210/pdb1f58/pdb
• 分子名称: PROTEIN (IGG1 ANTIBODY 58.2 (LIGHT CHAIN)), PROTEIN (IGG1 ANTIBODY 58.2 (HEAVY CHAIN)), Envelope glycoprotein gp120, ... (4 entities in total)
• 機能のキーワード: immunoglobulin, fab, hiv-1, gp120, v3, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 51162.98

構造登録者

Stanfield, R.L.,Cabezas, E.,Satterthwait, A.C.,Stura, E.A.,Profy, A.T.,Wilson, I.A. (登録日: 1998-10-21, 公開日: 1999-02-02, 最終更新日: 2024-04-03)

主引用文献

Stanfield, R.,Cabezas, E.,Satterthwait, A.,Stura, E.,Profy, A.,Wilson, I.
Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs.
Structure Fold.Des., 7:131-142, 1999

PubMed Abstract: The third hypervariable (V3) loop of HIV-1 gp120 has been termed the principal neutralizing determinant (PND) of the virus and is involved in many aspects of virus infectivity. The V3 loop is required for viral entry into the cell via membrane fusion and is believed to interact with cell surface chemokine receptors on T cells and macrophages. Sequence changes in V3 can affect chemokine receptor usage, and can, therefore, modulate which types of cells are infected. Antibodies raised against peptides with V3 sequences can neutralize laboratory-adapted strains of the virus and inhibit syncytia formation. Fab fragments of these neutralizing antibodies in complex with V3 loop peptides have been studied by X-ray crystallography to determine the conformation of the V3 loop.

PubMed: 10368281
DOI: 10.1016/S0969-2126(99)80020-3

実験手法

X-RAY DIFFRACTION (2 Å)