1F1J

CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-ASP-GLU-VAL-ASP-CHO

Summary for 1F1J

Entry DOI	10.2210/pdb1f1j/pdb
Related PRD ID	PRD_000422
Descriptor	CASPASE-7 PROTEASE, ACE-ASP-GLU-VAL-ASP-CHO, SULFATE ION, ... (4 entities in total)
Functional Keywords	caspase-7, cysteine protease, hydrolase, apoptosis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P55210
Total number of polymer chains	4
Total formula weight	70269.17
Authors	Wei, Y.,Charifson, P.S. (deposition date: 2000-05-19, release date: 2001-05-23, Last modification date: 2013-07-03)
Primary citation	Wei, Y.,Fox, T.,Chambers, S.P.,Sintchak, J.,Coll, J.T.,Golec, J.M.,Swenson, L.,Wilson, K.P.,Charifson, P.S. The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity. Chem.Biol., 7:423-432, 2000 Cited by PubMed Abstract: Peptide inhibitors of caspases have helped define the role of these cysteine proteases in biology. Structural and biochemical characterization of the caspase enzymes may contribute to the development of new drugs for the treatment of caspase-mediated inflammation and apoptosis. PubMed: 10873833 DOI: 10.1016/S1074-5521(00)00123-X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation