1F1J

CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-ASP-GLU-VAL-ASP-CHO

1F1J の概要

• エントリーDOI: 10.2210/pdb1f1j/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000422
• 分子名称: CASPASE-7 PROTEASE, ACE-ASP-GLU-VAL-ASP-CHO, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: caspase-7, cysteine protease, hydrolase, apoptosis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P55210
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 70269.17

構造登録者

Wei, Y.,Charifson, P.S. (登録日: 2000-05-19, 公開日: 2001-05-23, 最終更新日: 2025-03-26)

主引用文献

Wei, Y.,Fox, T.,Chambers, S.P.,Sintchak, J.,Coll, J.T.,Golec, J.M.,Swenson, L.,Wilson, K.P.,Charifson, P.S.
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
Chem.Biol., 7:423-432, 2000

PubMed Abstract: Peptide inhibitors of caspases have helped define the role of these cysteine proteases in biology. Structural and biochemical characterization of the caspase enzymes may contribute to the development of new drugs for the treatment of caspase-mediated inflammation and apoptosis.

PubMed: 10873833
DOI: 10.1016/S1074-5521(00)00123-X

実験手法

X-RAY DIFFRACTION (2.35 Å)