1F16

SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX

1F16 の概要

• エントリーDOI: 10.2210/pdb1f16/pdb
• 分子名称: PROTEIN (APOPTOSIS REGULATOR BAX, MEMBRANE ISOFORM ALPHA) (1 entity in total)
• 機能のキーワード: helical protein, apoptosis
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential): Q07812
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21204.35

構造登録者

Suzuki, M.,Youle, R.J.,Tjandra, N. (登録日: 2000-05-18, 公開日: 2000-11-22, 最終更新日: 2024-05-22)

主引用文献

Suzuki, M.,Youle, R.J.,Tjandra, N.
Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell(Cambridge,Mass.), 103:645-654, 2000

PubMed Abstract: Apoptosis is stimulated by the insertion of Bax from the cytosol into mitochondrial membranes. The solution structure of Bax, including the putative transmembrane domain at the C terminus, was determined in order to understand the regulation of its subcellular location. Bax consists of 9 alpha helices where the assembly of helices alpha1 through alpha 8 resembles that of the apoptosis inhibitor, Bcl-x(L). The C-terminal alpha 9 helix occupies the hydrophobic pocket proposed previously to mediate heterodimer formation and bioactivity of opposing members of the Bcl-2 family. The Bax structure shows that the orientation of helix alpha 9 provides simultaneous control over its mitochondrial targeting and dimer formation.

PubMed: 11106734
DOI: 10.1016/S0092-8674(00)00167-7

実験手法

SOLUTION NMR