1F13

RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII

Summary for 1F13

• Entry DOI: 10.2210/pdb1f13/pdb
• Descriptor: CELLULAR COAGULATION FACTOR XIII ZYMOGEN (2 entities in total)
• Functional Keywords: coagulation, transglutaminase, transferase, acyltransferase, blood coagulation, coagulation factor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00488
• Total number of polymer chains: 2
• Total formula weight: 166467.84

Authors

Weiss, M.S.,Hilgenfeld, R. (deposition date: 1998-01-16, release date: 1998-08-12, Last modification date: 2024-05-22)

Primary citation

Weiss, M.S.,Metzner, H.J.,Hilgenfeld, R.
Two non-proline cis peptide bonds may be important for factor XIII function.
FEBS Lett., 423:291-296, 1998

PubMed Abstract: The structure of recombinant human cellular factor XIII zymogen was solved in its monoclinic crystal form and refined to an R-factor of 18.3% (Rfree = 23.6%) for all data between 40.0 and 2.1 A resolution. Two non-proline cis peptide bonds were detected. One is between Arg310 and Tyr311 close to the active site cysteine residue (Cys314) and the other is between Gln425 and Phe426 at the dimerization interface. The structure and the role of these cis peptides are discussed in the light of their possible importance for factor XIII function.

PubMed: 9515726
DOI: 10.1016/S0014-5793(98)00098-2

Experimental method

X-RAY DIFFRACTION (2.1 Å)