1F13

RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII

1F13 の概要

• エントリーDOI: 10.2210/pdb1f13/pdb
• 分子名称: CELLULAR COAGULATION FACTOR XIII ZYMOGEN (2 entities in total)
• 機能のキーワード: coagulation, transglutaminase, transferase, acyltransferase, blood coagulation, coagulation factor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00488
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 166467.84

構造登録者

Weiss, M.S.,Hilgenfeld, R. (登録日: 1998-01-16, 公開日: 1998-08-12, 最終更新日: 2024-05-22)

主引用文献

Weiss, M.S.,Metzner, H.J.,Hilgenfeld, R.
Two non-proline cis peptide bonds may be important for factor XIII function.
FEBS Lett., 423:291-296, 1998

PubMed Abstract: The structure of recombinant human cellular factor XIII zymogen was solved in its monoclinic crystal form and refined to an R-factor of 18.3% (Rfree = 23.6%) for all data between 40.0 and 2.1 A resolution. Two non-proline cis peptide bonds were detected. One is between Arg310 and Tyr311 close to the active site cysteine residue (Cys314) and the other is between Gln425 and Phe426 at the dimerization interface. The structure and the role of these cis peptides are discussed in the light of their possible importance for factor XIII function.

PubMed: 9515726
DOI: 10.1016/S0014-5793(98)00098-2

実験手法

X-RAY DIFFRACTION (2.1 Å)