1F0I

THE FIRST CRYSTAL STRUCTURE OF A PHOSPHOLIPASE D

1F0I の概要

• エントリーDOI: 10.2210/pdb1f0i/pdb
• 分子名称: PHOSPHOLIPASE D, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: phospholipase d, alpha-beta-alpha-beta-alpha structure, hydrolase
• 由来する生物種: Streptomyces sp.
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53912.12

構造登録者

Leiros, I.,Secundo, F.,Zambonelli, C.,Servi, S.,Hough, E. (登録日: 2000-05-16, 公開日: 2001-05-16, 最終更新日: 2024-10-30)

主引用文献

Leiros, I.,Secundo, F.,Zambonelli, C.,Servi, S.,Hough, E.
The first crystal structure of a phospholipase D.
Structure Fold.Des., 8:655-667, 2000

PubMed Abstract: The phospholipase D (PLD) superfamily includes enzymes that are involved in phospholipid metabolism, nucleases, toxins and virus envelope proteins of unknown function. PLD hydrolyzes the terminal phosphodiester bond of phospholipids to phosphatidic acid and a hydrophilic constituent. Phosphatidic acid is a compound that is heavily involved in signal transduction. PLD also catalyses a transphosphatidylation reaction in the presence of phosphatidylcholine and a short-chained primary or secondary alcohol.

PubMed: 10873862
DOI: 10.1016/S0969-2126(00)00150-7

実験手法

X-RAY DIFFRACTION (1.4 Å)